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| Dosages: | PAC, PVCs, PAT, paroxysmal AV junctional rhythm, paroxysmal ventricular tachycardia, maintenance of cardioversion-
Child: Test dose: 2 mg/kg, then 30 mg/kg/day PO or 900 mg/m2/day PO in 5 divided doses.
Adult: Test dose: 50-200 mg (sulfate) PO or 200 mg (gluconate) IM; then 200-400 mg (sulfate) PO or equivalent base q 4-6 h; or 600 mg (gluconate) IM, then up to 400 mg q 2 h prn; or 800 mg (gluconate) IV dil in 40 ml D5W at 16 mg (1 ml)/min. Or 300-600 mg (sulfate ext-rel) or 324-648 mg (gluconate extended-release) q 8-12 h.
Atrial flutter, atrial fibrillation-
Adult: 200 mg (sulfate or equivalent base) PO q 2-3 h × 5-8 doses with qd increase until sinus rhythm or toxic effect develop. Give only after digitalization to avoid increasing AV conduction. Max 3-4 gram qd. Maintenance: 200-400 mg PO tid-qid or 600 mg PO q 8-12 h qd (ext-rel).
PSVT-
Adult: 400-600 mg (sulfate) PO q 2-3 h until toxic effects develop or arrhythmia subsides.
Malaria (when quinine dihydrochloride unavailable)-
Adult: Loading dose: 10 mg/kg dil in 250 ml NSS inj IV over 1-2 h, then continue infusion 0.02 mg/kg/min (20 mcg/kg/min) × 72 h or until parasitemia reduced to < 1% or PO treatment can begin; or 10 mg/kg (sulfate) PO q 8 h × 5-7 day. |
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